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Manikiran, S. S.
- Aquasomes: Role to Deliver Bioactive Substances
Authors
1 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, IN
2 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034 Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 6 (2010), Pagination: 356-360Abstract
Aquasomes are one of the most recently developed delivery systems; these are nanoparticulate carrier systems with three-layered self-assembled structures. They comprise a central solid nanocrystalline core coated with polyhydroxyoligomers onto which biochemically active molecules are adsorbed. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. The brushite is unstable and converts to hydroxyapatite upon prolong storage. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. It is widely used for the preparation of implants for drug delivery. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.Keywords
Aquasomes, Nanoparticels, Bioactives, Nanocrystalline Core.
- Effect of Solid Dispersion Technique on Improving the Solubility of Roxithromycin
Authors
1 Aurobindo Pharma Ltd., Hyderabad, IN
2 Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522034, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 184-188Abstract
Roxithromycin, an antibacterial agent is widely used in the treatment of various infections. One of the major problem with this drug is its low solubility in biological fluids. Therefore, solid dispersions of roxithromycin were prepared using mannitol as carrier by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method to improve the aqueous solubility. Solid dispersions were prepared in 1:1, 1:2, 1:4 and 1:9 ratios of drug to carrier. Prepared solid dispersions were evaluated for solubility, content uniformity, dissolution rate and efficiency. More solubility and faster dissolution was exhibited by solid dispersions containing 1:4 ratio of drug and carrier prepared by melting method. FT-IR studies revealed the absence of significant drug-carrier interactions.